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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
intermediary metabolism and respiration
regulatory proteins
conserved hypotheticals
lipid metabolism
General annotation
ProductPossible antitoxin VapB47
CommentsRv3407, (MTCY78.21c), len: 99 aa. Possible vapB47, antitoxin, part of toxin-antitoxin (TA) operon with Rv3408, see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E(): 0.00021, (37.1% identity in 89 aa overlap); O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 155, E(): 0.00051, (41.05% identity in 78 aa overlap), MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc.
Functional categoryVirulence, detoxification, adaptation
ProteomicsThe product of this CDS corresponds to spot 6_52 identified by proteomics at the Max Planck Institute for Infection Biology, Berlin, Germany (see Mattow et al., 2001). Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
TranscriptomicsmRNA identified by DNA microarray analysis and possibly down-regulated by hspR|Rv0353 (see Stewart et al., 2002).
MutantDisruption of this gene provides a growth advantage for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3407|vapB47