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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown; probably involved in cellular metabolism.
ProductPossible oxidoreductase
CommentsRv3553, (MTCY03C7.02c), len: 355 aa. Possible oxidoreductase, highly similar (except in C-terminus) to Q9A327|CC3379 hypothetical protein from Caulobacter crescentus (321 aa), FASTA scores: opt: 639, E(): 4.6e-29, (46.35% identity in 248 aa overlap); and Q9WZQ7|TM0800 conserved hypothetical protein from Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): 4.1e-28, (37.95% identity in 340 aa overlap). Also similar to two trans-2-enoyl-ACP reductases; Q99YD4|FABK|SPY1751 from Streptococcus pyogenes (323 aa), FASTA scores: opt: 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and Q9FBC5|FABK from Streptococcus pneumoniae (324 aa), FASTA scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa overlap); and similar with several 2-nitropropane dioxygenases, e.g. Q9F7P8 from uncultured proteobacterium EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21, (33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus (274 aa), FASTA scores: opt: 456, E(): 8.9e-19, (36.3% identity in 237 aa overlap); etc.
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, but essential for in vitro growth on cholesterol; by sequencing of Himar1-based transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS39916213992688+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3553|Rv3553
MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITHLQTASALVE