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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionPossibly plays a regulatory role in celular differentiation.
ProductConserved hypothetical protein
CommentsRv3661, (MTV025.009), len: 287 aa. Conserved hypothetical protein, highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphological differentiation in Streptomyces azureus (belongs to the SerB family) (277 aa) FASTA scores: opt: 1073, E(): 3.5e-61, (61.45% identity in 262 aa overlap); and Q9X923|SCH5.21 putative morphological differentiation-associated protein from Streptomyces coelicolor (268 aa), FASTA scores: opt: 1057, E(): 3.6e-60, (61.45% identity in 262 aa overlap). Also similar to various bacterial proteins (principally serB-related proteins) e.g. Q49823|ML2424 hypothetical SERB protein from Mycobacterium leprae (300 aa), FASTA scores: opt: 452, E(): 1.4e-21, (35.8% identity in 257 aa overlap); Q9WX12|SCE68.20 hypothetical 32.0 KDA protein from Streptomyces coelicolor (298 aa), FASTA scores: opt: 415, E(): 3.1e-19, (33.55% identity in 280 aa overlap); Q9RIT2|SERB phosphoserine phosphatase (fragment) from Streptomyces coelicolor (266 aa), FASTA scores: opt: 405, E(): 1.2e-18, (34.1% identity in 261 aa overlap); etc. Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c hypothetical 39.5 KDA protein from Mycobacterium tuberculosis (373 aa), FASTA scores: opt: 454, E(): 1.2e-21, (35.15% identity in 276 aa overlap). Belongs to the SerB family.
Functional categoryVirulence, detoxification, adaptation
ProteomicsIdentified in the cytosol of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 90 days but not 30 days (See Kruh et al., 2010).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40996474100510+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3661|Rv3661
VTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGKYTGEVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVTYALLRRFAFQP