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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductHypothetical protein
CommentsRv3785, (MTCY13D12.19), len: 357 aa. Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-dependent epimerase/dehydratase family protein from Mycobacterium tuberculosis strain CDC1551 (712 aa), but shorter 355 aa.
Functional categoryConserved hypotheticals
ProteomicsIdentified in the cytosol of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010).
MutantDisruption of this gene provides a growth advantage for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS42313204232393+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3785|Rv3785
MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMFGGAFPQTDHLEARLASLDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLDLPAKKRDAIVGLAQQLGLTLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQVGHIVLAAASRRLLPSEDDAVAVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDDNPHRDSMVWRFAADTNDLGVPITLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCLLVTGQPFVPYQNFDALRTLALPFGIQVETVGFGIDRYDGLGELDQQHPAKLLQEVRSTIRAARALLERIEAGERMATDPRR