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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPossible conserved transmembrane protein
CommentsRv3807c, (MTV026.12), len: 165 aa. Possible conserved transmembrane protein, equivalent to Q9CDB6|ML0094 putative membrane protein from Mycobacterium leprae (192 aa), FASTA scores: opt: 714, E(): 2.4e-38, (72.85% identity in 151 aa overlap). Also highly similar to Q9KZA3|SC5G8.11 putative integral membrane protein from Streptomyces coelicolor (169 aa), FASTA scores: opt: 324, E(): 1.1e-13, (41.5% identity in 159 aa overlap); and similar in part to others e.g. Q9K3L3|SCG20A.27 putative integral membrane protein from Streptomyces coelicolor (230 aa), FASTA scores: opt: 277, E(): 1.3e-10, (41.65% identity in 168 aa overlap); P72269|ORF8 hypothetical protein from Rhodococcus erythropolis (487 aa) FASTA scores: opt: 229, E(): 2.7e-07, (36.25% identity in 149 aa overlap); O86625|SC3A7.24c putative integral membrane protein from Streptomyces coelicolor (201 aa) FASTA scores: opt: 200, E(): 9.1e-06, (34.95% identity in 146 aa overlap); Q9KYD7|SCD72A.19 putative integral membrane protein from Streptomyces coelicolor (238 aa) FASTA scores: opt: 178, E(): 0.00026, (35.7% identity in 112 aa overlap); etc. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
Functional categoryCell wall and cell processes
ProteomicsIdentified by mass spectrometry in Triton X-114 extracts of M. tuberculosis H37Rv (See Malen et al., 2010). Identified by mass spectrometry in the membrane protein fraction and whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate (See de Souza et al., 2011).
MutantEssential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Required for survival in primary murine macrophages, by transposon site hybridization (TraSH) in H37Rv (See Rengarajan et al., 2005). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS42698404270337-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3807c|Rv3807c
MVAVQSALVDRPGMLATARGLSHFGEHCIGWLILALLGAIALPRRRREWLVAGAGAFVAHAIAVLIKRLVRRQRPDHPAIAVNVDTPSQLSFPSAHATSTTAAALLMGRATGLPLPVVLVPPMALSRILLGVHYPSDVAVGVALGATVGAIVDSVGGGRQRARKR