Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved protein
CommentsRv3860, (MTCY01A6.08c), len: 390 aa. Conserved protein, showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa), FASTA scores: opt: 484, E(): 5.5e-14, (29.95% identity in 407 aa overlap); O33082|MLCB628.11c (478 aa) FASTA scores: opt: 484, E(): 4.8e-14, (29.95% identity in 407 aa overlap); etc. Also some similarity with O86637|SC3C3.03c hypothetical 112.1 KDA protein from Streptomyces coelicolor(1083 aa), FASTA scores: opt: 483, E(): 9.6e-14, (30.45% identity in 404 aa overlap). And some similarity with other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O05456|Rv3888c|MTCY15F10.24 hypothetical 37.7 KDA protein (341 aa), FASTA scores: opt: 603, E(): 2.8e-19, (35.2% identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09 hypothetical 43.0 KDA protein (405 aa), FASTA scores: opt: 538, E(): 2e-16, (31.0% identity in 371 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 475, E(): 1.5e-13, (30.2% identity in 391 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryConserved hypotheticals
ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS43367774337949+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3860|Rv3860
MYERDEFLRDRIRPHQPGTPRGYSPRPPSGDRCPAPPPGRHAAAATPPGPPRLPSAPLRPLPDPAWPRQPEAPPPSTWADPALAPIRSRTRPGERGWRRMVRLVTFGLVGLGRSGMQRQEAQFEATIRTVLHGNHKVAVLGKGGVGKTSVAACVGSILAELRQQDRIVGIDADTAFGRLSSRIDPRAAGSFWELTTDTNLRSFTDITARLGRNSAGLYVLAGQPASGPRRVLDPAIYREAALRLDHHFAISVIDCGSSMEAAVTQEVLRDVDALIVVSSPWADGASAAANTIEWLSDYGLTGLLRRSIVVLNDSDGHADKRTKSLLAQEFIDHGQPVVEVPFDPHLRPGGVIDMSHEMAPTTRLKILQVAATVTAYFASRPADAHGSPPR