Gene ML0875
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN AEROBIC RESPIRATION. SUBUNIT I AND II FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. ELECTRONS ORIGINATING IN CYTOCHROME C ARE TRANSFERRED VIA HEME A AND CU(A) TO THE BINUCLEAR CENTER FORMED BY HEME A3 AND CU(B) [Catalytic activity: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O] |
| Product | PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC |
| Comments | ML0875, len: 353 aa. Probable ctaC, transmembrane cytochrome C oxidase (subunit II). Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide II precursor ctaC or Rv2200c or MTCY190.11C SW:COX2_MYCTU (Q10375) (363 aa) fasta scores: E(): 0, 85.3% identity in 340 aa. Shows weak similarity to many cytochrome oxidases e.g. to part of Acanthamoeba castellanii cytochrome C oxidase polypeptide I+II cox1/2 SW:COX1_ACACA (Q37370) (873 aa) fasta scores: E(): 7.1e-10, 28.5% identity in 221 aa. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00116 COX2, Cytochrome C oxidase subunit II. Contains PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. Belongs to the cytochrome c oxidase subunit 2 family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1039785 | 1040846 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0875|ctaC
VTARELVCSQRVGQGLSRRLRPLVLAVTLGVLVVTLSGCSWSDALAIGWPEGITPEAHLNRQLWIGAVVASLVVGVIVWGLIFWSTIFHRKKTTDTELPRQFGYNMPLELVLTVTPFLIISMLFYFTVIVQDKMLYLAKDPEVVIDVTAFQWNWKFGYQRVDFKDGTLTYDGVDPARKKAMVSKPEGKDSHGEELVGAVRGLNTEDRAYLNFDKVETLGTTTEIPVLVLPAGKRIEFQLNSADVVHSFWVPKFLFKRDVMPNPVANNSVNVFQVEEITKTGAFVGHCAEMCGTYHSMMNFEVRVVAPNDFKAYLQQRIDGKTNAEALQVIAQPPLAVTTHPFDTRRGQLTNSQ
Bibliography
No article yet recorded
