Gene ML0987
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN REGULATION OF NUCLEOTIDE EXCISION REPAIR, IN GENETIC RECOMBINATION, AND IN INDUCTION OF THE SOS RESPONSE. ENDONUCLEASE WHICH CAN CATALYZE THE HYDROLYSIS OF ATP IN THE PRESENCE OF SINGLE-STRANDED DNA, THE ATP-DEPENDENT UPTAKE OF SINGLE-STRANDED DNA BY DUPLEX DNA, AND THE ATP-DEPENDENT HYBRIDIZATION OF HOMOLOGOUS SINGLE-STRANDED DNAS. IT INTERACTS WITH LEXA CAUSING ITS ACTIVATION AND LEADING TO ITS AUTOCATALYTIC CLEAVAGE. |
| Product | RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. |
| Comments | ML0987, len: 711 aa. Probable RecA protein (EC 3.1.-.-). Identical to the previously sequenced and characterised Mycobacterium leprae RecA protein involved in DNA recombination and the SOS response SW:RECA_MYCLE (P35901) (711 aa), Fasta scores: E(): 0, 100.0% identity in 711 aa overlap. Also highly similar to many others e.g. Mycobacterium tuberculosis Rv2737c SW:RECA_MYCTU (P26345) (790 aa), Fasta scores: E(): 0, 46.7% identity in 814 aa overlap. Note the Mycobacterium leprae RecA protein is known to possess an intron which is self-spliced at the post-translational level. Contains 2 Pfam matches to entry PF00154 recA, recA bacterial DNA recombination proteins. Contains PS00321 recA signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00881 Protein splicing signature. Belongs to the recA family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1153059 | 1155194 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0987|recA
MAQVPDREKALELAMAQIEKNYGKGSVMRLGDEMCQPISVIPTGSIALDVALGIGGLPRGRIVEIYGPESSGKTTVALHAVANAQAVGGVAAFIDAEHALEPEYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEGEMGDSYVGLQARLMSQALRKMTGALSNSGTTAIFINQLREKIGVMFGCMNYSTRVTLADGSTEKIGKIVNNKMDVRVLSYDPVTDRIVPRKVVNWFNNGPAEQFLQFTVEKSGSNGKSQFAATPNHLIRTPGGWTEAGNLIAGDRVLAVEPHMLSDQQFQVVLGSLMGDGNLSPNLCDRNGVRFRLLGYGCKQVEYLQWKKALMGNIRHTVRENSMGASFIDFTPLPELVELQRAVYLGDGKKFLSEEYLKALTPLVLAIWYMDDGSFTVGSKRVQERTAGGSGRIEICVDAMTEGTRVRLRDYLCDTHGLDVRLREVGSAGKAVLVFSTAATAKFQSLIAPYVAPSMEYKLLPQFRGRGSVTPQFVEPTQQLVPARVLDVHVKLSTRSMNRFDIEVEGNHNYFVDGVMVHNSPETTTGGKALKFYASVRMDVRRIETLKDGVDAVGNRTRVKIVKNKVSPPFKQAEFDILYGKGISREGSLIDMGVEQGFVRKSGSWFTYEGEQLGQGKENARNFLLENADVANEIEKKIKEKLGIGAVVTDDDILPTPVDF
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