Gene ML1022c (rpoT)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | RNA polymerase sigma factor SigA |
| Comments | ML1022c, len: 574 aa. Probable sigA (also known as rpoT), RNA polymerase sigma factor. Identical to the previously sequenced Mycobacterium leprae RNA polymerase sigma factor, rpoT TR:Q59532 (EMBL:U15181) (574 aa), Fasta scores: E(): 0, 99.8% identity in 574 aa overlap. Also highly similar to many other proposed sigma factors e.g. Mycobacterium tuberculosis SigA (RpoD), RNA polymerase sigma factor Rv2703 SW:RPSA_MYCTU (Q60162) (528 aa), Fasta scores: E(): 0, 80.5% identity in 533 aa overlap. The C-terminus is highly similar to ML1014 from M. leprae. Contains a probable helix-turn-helix motif at aa 533-554 (Score 1603, SD +4.65) Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor. Contains PS00716 Sigma-70 factors family signature 2. Contains PS00715 Sigma-70 factors family signature 1. Belongs to the sigma-70 factor family. Previously known as rpoT. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1189188 | 1190912 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1022c|sigA
VEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNPPEVSPTEGVYVVATKTSPATGQPVKRTATKTPATPAKRSTTKAANGSAPTKRATSTASRATKSTTPPKASGASDAAKKARTSVKSVDTKAPSAQDHTTKASAAKDTLNDPEATLNTLDSDATADDLDAEPDLDVEPSEDIDIDIEAADLGLDDLEDDDVVTDIEPGETEDGEATAATKTDEASTDDDEEIVEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Bibliography
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