Gene ML1076
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE |
| Comments | ML1076, len: 263 aa. sigE, alternative sigma factor of extracytoplasmic function (ECF) family. Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE Rv1221 TR:O06289 (EMBL:U87242) (257 aa), Fasta scores: E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa), Fasta scores: E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa), Fasta scores: E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a possible helix-turn-helix motif situated between residues 213..234 (+3.09 SD). Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1239343 | 1240134 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1076|sigE
MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPTIMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVYWLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLLTAHPRDGATTDATHVKSA
Bibliography
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