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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE BIOTIN SYNTHETASE BIOB
CommentsML1220, len: 345 aa. Probable bioB, biotin synthetase (EC 2.8.1.-). Identical to the previously sequenced Mycobacterium leprae biotin synthase SW:BIOB_MYCLE (P46715) (345 aa), Fasta scores: E(): 0, 99.1% identity in 345 aa overlap. Also highly similar to several others involved in biotin biosynthesis e.g. Escherichia coli SW:BIOB_ECOLI (P12996) (346 aa), Fasta scores: E(): 0, 35.3% identity in 309 aa overlap and Mycobacterium tuberculosis Rv1589 TR:BIOB_MYCTU (349 aa), fasta scores: E(): 5.9e-131, (87.106% identity in 349 aa overlap). Contains Pfam match to entry PF01792 Biotin_synth, Biotin synthase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14425051443542+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1220|bioB
VTQAGTRSTNGDTENTDILAQARQQVLERGEGLSRDQVLQMLWLPDDRLEELLALAHDVRMRWCGPEVEIEGIISLKTGGCPEDCHFCSQSGLFMSPVRSAWLDIRSLVEAAKQTAKSGATEFCIVAAVRGPDERLMSQVAAGIEAIRNEVEINIACSLGMLTVEQVEQLSGIGVHRYNHNLETARSFFTNVVTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETVEQRAEFALELAELGPDEVPLNFLNPRPGTPFGALEVMPPSEALKSVAAFRLALPRTILRFAGGREITLGDLGAKQGMLGGINAVIVGNYLTTLGRPAEADLRLLDDLQMPIKALNASL
      
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