Gene ML1220 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namebioB
Gene length1038 bp
IdentifierML1220
Location 1442505 bp
Protein summary information
Molecular mass37525.8 Da
Isoelectric point4.55
Protein length346 amino acids
Structural information
PFAMPF04055, PF06968
Orthologs
M. tuberculosis H37RvRv1589
M. lepromatosis Mx1-22AMLPM_1220
Cross-references
UniProtP46715
Gene Ontology4 iron, 4 sulfur cluster binding, Biotin biosynthetic process, Biotin synthase activity, Iron ion binding, 2 iron, 2 sulfur cluster binding
Enzyme Classification2.8.1.6
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE BIOTIN SYNTHETASE BIOB
CommentsML1220, len: 345 aa. Probable bioB, biotin synthetase (EC 2.8.1.-). Identical to the previously sequenced Mycobacterium leprae biotin synthase SW:BIOB_MYCLE (P46715) (345 aa), Fasta scores: E(): 0, 99.1% identity in 345 aa overlap. Also highly similar to several others involved in biotin biosynthesis e.g. Escherichia coli SW:BIOB_ECOLI (P12996) (346 aa), Fasta scores: E(): 0, 35.3% identity in 309 aa overlap and Mycobacterium tuberculosis Rv1589 TR:BIOB_MYCTU (349 aa), fasta scores: E(): 5.9e-131, (87.106% identity in 349 aa overlap). Contains Pfam match to entry PF01792 Biotin_synth, Biotin synthase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14425051443542+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1220|bioB
VTQAGTRSTNGDTENTDILAQARQQVLERGEGLSRDQVLQMLWLPDDRLEELLALAHDVRMRWCGPEVEIEGIISLKTGGCPEDCHFCSQSGLFMSPVRSAWLDIRSLVEAAKQTAKSGATEFCIVAAVRGPDERLMSQVAAGIEAIRNEVEINIACSLGMLTVEQVEQLSGIGVHRYNHNLETARSFFTNVVTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETVEQRAEFALELAELGPDEVPLNFLNPRPGTPFGALEVMPPSEALKSVAAFRLALPRTILRFAGGREITLGDLGAKQGMLGGINAVIVGNYLTTLGRPAEADLRLLDDLQMPIKALNASL
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