Gene ML1546c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametruB
Gene length963 bp
IdentifierML1546c
Location 1871005 bp
Protein summary information
Molecular mass34180.1 Da
Isoelectric point6.79
Protein length321 amino acids
Structural information
PFAMPF01509, PF09142
Orthologs
M. tuberculosis H37RvRv2793c
M. lepromatosis Mx1-22AMLPM_1546
Cross-references
UniProtQ9Z5I4
Gene OntologyTrna pseudouridine synthesis, Pseudouridine synthase activity
Enzyme Classification5.4.99.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRNA PSEUDOURIDINE SYNTHASE B TRUB (TRNA PSEUDOURIDINE 55 SYNTHASE) (PSI55 SYNTHASE) (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
CommentsML1546c, len: 320 aa. Probable tRNA pseudouridine 55 synthase (EC 4.2.1.70). Highly similar to many tRNA pseudouridine synthases B including: Escherichia coli SW:TRUB_ECOLI (X13270) (314 aa), Fasta scores: E(): 1.7e-19, 36.4% identity in 316 aa overlap and Mycobacterium tuberculosis Rv2793c SW:TRUB_MYCTU (O33335) (298 aa), Fasta scores: E(): 0, 74.1% identity in 293 aa overlap. Contains Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain).
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18710051871967-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1546c|truB
MSESSTGAGLGPGIVVIDKPSGMTSHDVVARCRRIFCTRRVGHAGTLDPMATGVLVLGVDRATKILGLLAGASKEYVATIRLGQTTSTEDAEGELLQCVSARHVTDEAIATAIGRLRGDIKQVPSAVSAIKVDGRRAYRLVREGHVVELQARPVRIDRFEVLAVRPGPEVGLADVIDLDVEVECSSGTYIRALARDLGDAFGVGGHLTSLRRTRVGRFELDQAWSLEDLAELPRLSRTLDETCLLMFPRRDLTVSEVEATSNGRPISSAGIDGIYAASDADGRVIALLRDEGPRTKSVVVLHPVFVRVSIGRGIVGVIEA
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