Gene ML2419c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemB
Gene length990 bp
IdentifierML2419c
Location 2893807 bp
Protein summary information
Molecular mass34743.0 Da
Isoelectric point4.45
Protein length330 amino acids
Structural information
PFAMPF00490
Orthologs
M. tuberculosis H37RvRv0512
M. lepromatosis Mx1-22AMLPM_2419
Cross-references
UniProtP46723
Gene OntologyPorphyrin-containing compound biosynthetic process, Zinc ion binding, Porphobilinogen synthase activity
Enzyme Classification4.2.1.24
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)
CommentsML2419c, len: 329 aa. Probable hemB, delta-aminolevulinic acid dehydratase (EC 4.2.1.24). Similar to many including: Mycobacterium tuberculosis delta-aminolevulinic acid dehydratase Rv0512 SW:HEM2_MYCTU (O33357) (329 aa) fasta scores: E(): 0, 87.5% identity in 329 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB SW:HEM2_ECOLI (P15002; P78247) (323 aa) fasta scores: E(): 0, 46.7% identity in 317 aa. Contains Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase. Contains PS00169 Delta-aminolevulinic acid dehydratase active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28938072894796-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML2419c|hemB
VSVSGYPRHRPRRLRSTPAMRRLVAQTSLEPRNLVLPMFVADGIDELRPIASMPGVVQHTRDSLRRAAVAAVDAGVGGLNLFGVPRDQDKDATGSAGVDPDGILNVALRDLAEDLGDATVLMADTCLDEFTDHGHCGVLDGQGRVDNDATVARYVELAVAQAESGANVVGPSGMMDGQIGALRDGLDSAGYADVAILAYAAKFSSAFYGPFREAVSCSLSGDRRTYQQEPGNAREALREIKLDLDEGADIIMIKPASGYLDVVATAAGVSPVPVAAYQVSGEYAMICAAAANNWIDERAAVLESLTSIRRAGADIVFTYWAADVACWLS
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