Gene MMAR_1886 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecysG
Gene length1206 bp
IdentifierMMAR_1886
Location 2298950 bp
Protein summary information
Molecular mass42037.5 Da
Isoelectric point6.16
Protein length402 amino acids
Structural information
PFAMB2HKR4
Orthologs
M. tuberculosis H37RvRv2847c
Cross-references
UniProtB2HKR4
Gene OntologyMethyltransferase activity, Oxidation-reduction process, Porphyrin-containing compound biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin]. SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation).
Productmultifunctional enzyme siroheme synthase CysG
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS22989502300155+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_1886|cysG
VTESPYLVGLRLTGRKVVVVGGGTVAQRRLPLLIASGADVQVISRSATRSVEVMDKITLTLREYRDGDLEGAWYAIAATDDPAVNAAIVAEADRRQIFCVRADIAVEGTAVTPATFNHAGLSVGVLASGDHRRSAAIRSAIREALQNGLVTSTSYQSSDVIRGGVALIGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERAKAGRFVVRLKGGDPFVFARGYEEVLACTEAGIPVIVVPGVTSAIAVPALAGVPVTHRATNHEFVVVSGHIAPDHPESLVNWNALAAMSGTIVLLMAVERIELFVEALLKGGRPADTPVLVVQHGTTPAQHTLRATLADTPEKVRAEGIRPPAIIVIGAVAAFGV
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