Gene Mb0005 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegyrB
Gene length2145 bp
IdentifierMb0005
Location 5123 bp
Protein summary information
Molecular mass78455.7 Da
Isoelectric point6.6057
Protein length714 amino acids
Orthologues
M. tuberculosisRv0005
Cross-references
UniProtA0A1R3XU15
InterProIPR001241, IPR002288, IPR003594, IPR006171, IPR011557, IPR013506, IPR013759, IPR013760, IPR014721, IPR018522, IPR020568
UniProtKB/TrEMBLQ7U312
General annotation
TypeCDS
FunctionUnknown
ProductDNA GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE (ATP-HYDROLYSING)) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE)
CommentsMb0005, gyrB, len: 714 aa. Equivalent to Rv0005,len: 714 aa, from Mycobacterium tuberculosis strain H37Rv,(99.9% identity in 714 aa overlap). gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below), equivalent,except in N-terminus, to other Mycobacterial DNA GYRASES SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa); Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp. paratuberculosis (677 aa) (has its N-terminus shorter); P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa); etc. Also highly similar to others e.g. T10969 from Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from Streptomyces spheroides (684 aa); etc. Contains PS00177 DNA topoisomerase II signature. BELONGS TO THE TYPE II TOPOISOMERASE FAMILY.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS51237267+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0005|gyrB
MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDSKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
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