Gene Mb0009 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppiA
Gene length549 bp
IdentifierMb0009
Location 12468 bp
Protein summary information
Molecular mass19239.4 Da
Isoelectric point6.2287
Protein length182 amino acids
Orthologs
M. tuberculosis H37RvRv0009
M. tuberculosis MTBC0mtbc0_000013
Cross-references
UniProtP65763
UniProtKB/TrEMBLX2BDS2, P65763
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A)
CommentsMb0009, ppiA, len: 182 aa. Equivalent to Rv0009,len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 182 aa overlap). Probable ppiA (alternate gene name: cfp22), iron-regulated peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8),equivalent to NP_301138.1|NC_002677 putative peptidyl-prolyl cis-trans isomerase from Mycobacterium leprae (182 aa), FASTA score: (90.1% identity in 182 aa overlap). Also highly similar to others e.g. T36725 from Streptomyces coelicolor (177 aa); T43805 from Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 from Treponema pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon has been suggested.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS1246813016+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0009|ppiA
MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVGLAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAISKTATDGNDRPTDPVVIESITIS
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