Gene Mb0042 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuS
Gene length2910 bp
IdentifierMb0042
Location 43546 bp
Protein summary information
Molecular mass107595.0 Da
Isoelectric point4.8663
Protein length969 amino acids
Orthologs
M. tuberculosis H37RvRv0041
M. tuberculosis MTBC0mtbc0_000046
Cross-references
UniProtP67511
UniProtKB/TrEMBLX2BDV0, P67511
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE LEUCYL-tRNA SYNTHETASE LEUS (LEUCINE--tRNA LIGASE) (LEURS)
CommentsMb0042, leuS, len: 969 aa. Equivalent to Rv0041,len: 969 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 969 aa overlap). Probable leucyl-tRNA synthetase (EC 6.1.1.4), equivalent to NP_301156.1|NC_002677|MLCB628_3 leucyl-tRNA synthase from Mycobacterium leprae (972 aa), FASTA score: (83.6% identity in 972 aa overlap); and highly similar to MLCB1770_20 from Mycobacterium leprae (824 aa), FASTA score: (82.8% identity in 824 aa overlap). Also highly similar to others e.g. CAB66249.1|AL136518 leucyl-tRNA synthetase from Streptomyces coelicolor (966 aa); NP_244147.1|NC_002570 leucyl-tRNA synthetase from Bacillus halodurans (806 aa); SYL_BACSU|P36430 leucyl-tRNA synthetase from Bacillus subtilis (804 aa), FASTA scores: opt: 714, E(): 3.1e-38, (43.7% identity in 938 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS4354646455+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0042|leuS
MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWARLGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLERQESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHRDAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPVQVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI
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