Gene Mb0170c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable transcriptional regulatory protein Mce1R (probably GntR-family) |
| Comments | Mb0170c, len: 230 aa. Equivalent to Rv0165c len: 223 aa, from Mycobacterium tuberculosis strain H37Rv,(81.2% identity in 218 aa overlap). Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa); GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 194315 | 195007 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0170c|mce1R
MNAPLSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFLLNAARYMPAQVFAADPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETEVFG
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