Gene Mb0228c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE ALDEHYDE DEHYDROGENASE |
| Comments | Mb0228c, -, len: 385 aa. Equivalent to Rv0223c,len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,(95.3% identity in 364 aa overlap). Probable aldehyde dehydrogenase (EC 1.2.1.-), similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa), FASTA scores: opt: 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. Also similar to Rv0768, Rv2858c, etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site; and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-c) leads to a shorter product,with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 487 aa). |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 264931 | 266088 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0228c|Mb0228c
MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQSIVSRESVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEALHRQGHRGGRSVGVRRRPSRGLGQRLLYPIHERRWRGKWHGQCG
Bibliography
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