Gene Mb0430c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiD
Gene length798 bp
IdentifierMb0430c
Location 508777 bp
Protein summary information
Molecular mass27510.5 Da
Isoelectric point5.5114
Protein length265 amino acids
Orthologs
M. tuberculosis H37RvRv0422c
M. tuberculosis MTBC0mtbc0_000443
Cross-references
UniProtP66914
UniProtKB/TrEMBLX2BF06, P66914
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)
CommentsMb0430c, thiD, len: 265 aa. Equivalent to Rv0422c,len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 265 aa overlap). Probable thiD,phosphomethylpyrimidine kinase (EC 2.7.4.7), equivalent to AL035159|MLCB1450_21 PHOSPHOMETHYLPYRIMIDINE KINASE from Mycobacterium leprae (279 aa), FASTA scores: opt: 1386,E(): 0, (77.8% identity in 266 aa overlap). Also highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN PHOSPHOMETHYLPYRIMIDINE KINASE from Haemophilus influenzae (269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity in 259 aa overlap). BELONGS TO THE THID FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS508777509574-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0430c|thiD
MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS
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