Gene Mb0448
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | 60 KDA CHAPERONIN 2 GROEL2 (PROTEIN CPN60-2) (GROEL PROTEIN 2) (65 KDA ANTIGEN) (HEAT SHOCK PROTEIN 65) (CELL WALL PROTEIN A) (ANTIGEN A) |
| Comments | Mb0448, groEL2, len: 540 aa. Equivalent to Rv0440,len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 540 aa overlap). groEL2 (alternate gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa chaperonin 2 (see first citation below). PURIFIED 65 kDa ANTIGEN CAN ELICIT A STRONG DELAYED-TYPE HYPERSENSITIVITY REACTION IN EXPERIMENTAL ANIMALS INFECTED WITH M. TUBERCULOSIS. THIS PROTEIN IS ONE OF THE MAJOR IMMUNOREACTIVE PROTEINS OF THE MYCOBACTERIA. THIS ANTIGEN CONTAINS EPITOPES THAT ARE COMMON TO VARIOUS SPECIES OF MYCOBACTERIA. Contains PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 529627 | 531249 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0448|groEL2
MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
Bibliography
No article yet recorded
