Gene Mb0525 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemB
Gene length990 bp
IdentifierMb0525
Location 605753 bp
Protein summary information
Molecular mass34799.4 Da
Isoelectric point4.5618
Protein length329 amino acids
Orthologs
M. tuberculosis H37RvRv0512
M. tuberculosis MTBC0mtbc0_000540
Cross-references
UniProtA0A1R3XVJ5
InterProIPR001731, IPR013785
UniProtKB/TrEMBLQ7U1W0
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)
CommentsMb0525, hemB, len: 329 aa. Equivalent to Rv0512,len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,(99.7% identity in 329 aa overlap). Probable hemB,delta-aminolevulinic acid dehydratase (EC 4.2.1.24),equivalent to 46723|HEM2_MYCLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE from Mycobacterium leprae (329 aa). Also highly similar to many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor (330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323 aa), FASTA scores: opt: 942, E(): 0,(47.6% identity in 317 aa overlap); etc. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. BELONGS TO THE ALADH FAMILY. COFACTOR: ZINC.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS605753606742+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0525|hemB
MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIELDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWAVDAAGWLT
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