Gene Mb1812
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | esx conserved component eccc5. esx-5 type vii secretion system protein. |
| Comments | Mb1812, -, len: 1391 aa. Similar to Rv1783 and Rv1784, len: 435 aa and 932 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 435 aa overlap and 99.9% identity in 932 aa overlap). Rv1783: Probable conserved membrane protein. Member of family of Mycobacterium tuberculosis hypothetical proteins including O05450|Rv3894c|MTY15F10.18|Z94121 (1396 aa), FASTA scores: opt: 542, E(): 1.5e-26, (31.4% identity in 440 aa overlap); Rv3447c, Rv0284, Rv3870, Rv1784, and Rv3871, all linked to ESAT-6 family gene. Similar to N-terminal part of Rv3894c (1396 aa), Rv1784 is similar to remainder of Rv3894c. Also similar to O33087|MLCB628.16C|Y14967 Hypothetical protein from Mycobacterium leprae (744 aa),(30.0% identity in 437 aa overlap) and equivalent to N-terminal part of Q9Z5I2|MLCB596.28|AL035472 hypothetical protein from Mycobacterium leprae (1345 aa), (86.4% identity in 397 aa overlap). Rv1784: Conserved hypothetical protein, member of family of Mycobacterium tuberculosis hypothetical proteins including Rv3447c,Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, all linked to ESAT-6 family genes. Probably ATP-binding membrane proteins. Similar to C-terminal region of 006264|Rv3447c (1236 aa), (36.2% identity in 930 aa overlap). Equivalent to C-terminal region of Mycobacterium leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 (1345 aa), (87.8% identity in 932 aa overlap); also similar to other hypothetical proteins e.g. MLCB628.14 from Mycobacterium leprae, (32.0% identity in 600 aa overlap); MLCB628.15 from Mycobacterium leprae, (35.0% identity in 280 aa overlap); and O86653|SC3C3.20|AL031231 ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 618, E(): 4.6e-30, (34.3% identity in 937 aa overlap). Contains two times PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis, a single base transversion (a-t) leads to a single product. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2009715 | 2013890 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1812|eccc5
MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGVVVVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDAMRAQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNFGVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVEPWYALVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRRHDAAGNARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQWEYVISAEGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWFFALTDQVSIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFDSLWASRTDTMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLMLSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLDALWGEIARRKAICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIMPTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGLGYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRPQLFTNSFTPLEVSVGGPDIEPVVAQPNGEMLESDDIEGGEDEDEEGVRTPKVGTVIIDQLRKIKFEPYRLWQPPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKHDQPPWTVDTSGPGANVLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTALTTVSRIPHVGEVAGPTDPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGEAGPVPDDGFGDVYLVIDNYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELRPPVRSGFGSRIELRLAAVEDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHTLVARPALGSTPDNVFECDSVVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQGVGAGGIAWAISELDLAPVYLNFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGASSAPPPAPGRPSAQVWLVDPRRQLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREPPPGLSAEELLSRSWWSGPEIFLIVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVTRTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVFVQVAATEVRR
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