Gene Mb2069c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepncA
Gene length561 bp
IdentifierMb2069c
Location 2272594 bp
Protein summary information
Molecular mass19582.6 Da
Isoelectric point4.1111
Protein length186 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_002176
M. tuberculosis H37RvRv2043c
Cross-references
UniProtA0A1R3Y026
InterProIPR000868
UniProtKB/TrEMBLI3NIF8
General annotation
TypeCDS
FunctionUnknown
Productpyrazinamidase/nicotinamidase pnca (pzase)
CommentsMb2069c, pncA, len: 186 aa. Equivalent to Rv2043c,len: 186 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 186 aa overlap). pncA,pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved in susceptibility or resistance to antituberculous drug pyrazinamide. FASTA scores: sptr|Q50575|Q50575 PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; 100.0% identity in 186 aa overlap.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22725942273154-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2069c|pncA
MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDDFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS
Bibliography
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