Gene Mb2184c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb2184c
Gene length621 bp
IdentifierMb2184c
Location 2402176 bp
Protein summary information
Molecular mass21614.5 Da
Isoelectric point4.9109
Protein length206 amino acids
Cross-references
UniProtA0A1R3Y0F7
InterProIPR001647, IPR009057, IPR011075, IPR015893
UniProtKB/TrEMBLQ7TYZ3
General annotation
TypeCDS
FunctionUnknown
ProductCONSERVED HYPOTHETICAL PROTEIN
CommentsMb2184c, -, len: 206 aa. Similar to 5' end of Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa,from Mycobacterium tuberculosis strain H37Rv, (96.3% identity in 107 aa overlap and 92.0% identity in 112 aa overlap). Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08,(51.042% identity in 96 aa overlap). Next gene, Rv2160c,is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a 4 bp insertion (*-ggaa) leads to a single product.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24021762402796-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2184c|Mb2184c
MPSADVGRQTRAQILRAAMDIASVKGLSGLSIGELAGRLGMSKSGLFRHFGAKEQLQLATVEAAVSVFEAEVVAPAMAAPPGVDRVRALMHAWVGYLERDVFPGGCFFAAAAADVDSQPGPVRDRIAATGRAGIAAITADVETAQRRGEIRADIEARQLAFELHAYAMEANWALLLLDDDGAGERARTAIDAALARVGTTQEGVES
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