Gene Mb2258 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameptpA
Gene length492 bp
IdentifierMb2258
Location 2486294 bp
Protein summary information
Molecular mass17892.0 Da
Isoelectric point6.5051
Protein length163 amino acids
Orthologues
M. tuberculosisRv2234
Cross-references
UniProtP65717
UniProtKB/TrEMBLX2BK81, P65717
General annotation
TypeCDS
FunctionUnknown
ProductPHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE)
CommentsMb2258, ptpA, len: 163 aa. Equivalent to Rv2234,len: 163 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 163 aa overlap). ptpA (alternate gene name: MPtpA), low molecular weight protein-tyrosine-phosphatase (see citations below) (EC 3.1.3.48), similar to other phosphotyrosine protein phosphatases e.g. P53433|PTPA_STRCO LOW MOLECULAR WEIGHT PROTEIN-TYROSINE PHOSPHATASE from Streptomyces coelicolor (164 aa), FASTA scores: opt: 455, E(): 3.3e -25, (49.7% identity in 155 aa overlap); PA1S_HUMAN|P24667 red cell acid phosphatase 1, FASTA score: (37.7% identity in 138 aa overlap); etc. Contains a phosphatase catalytic site domain located in N-terminal part. Activity proven biochemically. Supposed a secreted protein.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24862942486785+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2258|ptpA
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
Bibliography
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