Gene Mb2361c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | integral membrane drug efflux protein stp |
| Comments | Mb2361c, -, len: 523 aa. Equivalent to Rv2333c,len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 508 aa overlap). Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug, highly similar to many e.g. Q9RL22|C5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 1031,E(): 4e-55, (37.4% identity in 412 aa overlap); Q9L0L9|SCD82.12 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (490 aa), FASTA scores: opt: 883,E(): 3.8e-46, (36.35% identity in 407 aa overlap); Q9ZBW5|SC4B5.03c PUTATIVE INTEGRAL MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (504 aa), FASTA scores: opt: 899, E(): 4.1e-47, (37.4% identity in 415 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 839, E(): 1.9e-43, (32.3% identity in 489 aa overlap); etc. Also highly similar to Rv2459|O53186|MTV008.15 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (508 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.05% identity in 504 aa overlap); and AAK46834|MT2534 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (523 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2584346 | 2585917 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2361c|stp
MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVASYSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTTARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPTLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWRWFPRDVQTAGSDAKREAAYSDDRRVRG
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