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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP TRIPHOSPHOHYDROLASE)
CommentsMb2373c, dgt, len: 431 aa. Equivalent to Rv2344c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable dgt,deoxyguanosine triphosphate triphosphohydrolase (EC 3.1.5.1), equivalent to Q9CCG3|DGT|ML0831 PUTATIVE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 2316,E(): 1.6e-137, (83.85% identity in 421 aa overlap); and O52199|DGTP_MYCSM|AF027507_2 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium smegmatis (428 aa),FASTA scores: opt: 1991, E(): 3.4e-117, (73.5% identity in 422 aa overlap). Also highly similar or similar to several deoxyguanosine triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c PUTATIVE DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Streptomyces coelicolor (424 aa),FASTA scores: opt: 1216, E(): 1e-68, (51.05% identity in 425 aa overlap); BAB48544|MLL1093 DGTP TRIPHOSPHOHYDROLASE from Rhizobium loti (Mesorhizobium loti) (404 aa), FASTA scores: opt: 489, E(): 3.1e-23, (33.85% identity in 387 aa overlap); P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022, (31.65% identity in 259 aa overlap); etc. BELONGS TO THE DGTPASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26000542601349-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2373c|dgt
MSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRARVLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPYGHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRASLDAVTKYPWMRGDGLGSQRRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREFSRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSELVGRFASAAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHLETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQIASYTEGRLERIDADQLGVSRNALD
      
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