Gene Mb2373c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedgt
Gene length1296 bp
IdentifierMb2373c
Location 2600054 bp
Protein summary information
Molecular mass46911.7 Da
Isoelectric point6.1545
Protein length431 amino acids
Orthologs
M. tuberculosis H37RvRv2344c
M. tuberculosis MTBC0mtbc0_002496
Cross-references
UniProtP0A541
UniProtKB/TrEMBLX2BKT4, P0A541
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT (DGTPASE) (DGTP TRIPHOSPHOHYDROLASE)
CommentsMb2373c, dgt, len: 431 aa. Equivalent to Rv2344c,len: 431 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 431 aa overlap). Probable dgt,deoxyguanosine triphosphate triphosphohydrolase (EC 3.1.5.1), equivalent to Q9CCG3|DGT|ML0831 PUTATIVE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 2316,E(): 1.6e-137, (83.85% identity in 421 aa overlap); and O52199|DGTP_MYCSM|AF027507_2 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Mycobacterium smegmatis (428 aa),FASTA scores: opt: 1991, E(): 3.4e-117, (73.5% identity in 422 aa overlap). Also highly similar or similar to several deoxyguanosine triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c PUTATIVE DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Streptomyces coelicolor (424 aa),FASTA scores: opt: 1216, E(): 1e-68, (51.05% identity in 425 aa overlap); BAB48544|MLL1093 DGTP TRIPHOSPHOHYDROLASE from Rhizobium loti (Mesorhizobium loti) (404 aa), FASTA scores: opt: 489, E(): 3.1e-23, (33.85% identity in 387 aa overlap); P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022, (31.65% identity in 259 aa overlap); etc. BELONGS TO THE DGTPASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26000542601349-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2373c|dgt
MSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRARVLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPYGHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRASLDAVTKYPWMRGDGLGSQRRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREFSRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSELVGRFASAAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHLETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQIASYTEGRLERIDADQLGVSRNALD
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