Gene Mb2407c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namembtI
Gene length1353 bp
IdentifierMb2407c
Location 2646724 bp
Protein summary information
Molecular mass48754.4 Da
Isoelectric point4.9874
Protein length450 amino acids
Cross-references
UniProtKB/TrEMBLX2BKI5, Q7TYQ1
SWISS-MODELQ7TYQ1
General annotation
TypeCDS
FunctionUnknown
Productisochorismate synthase mbti
CommentsMb2407c, mbtI, len: 450 aa. Equivalent to Rv2386c,len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 450 aa overlap). Putative mbtI,isochorismate synthase (see citations below), similar to Q9X9I8|IRP9 SALICYLATE SYNTHETASE from Yersinia enterocolitica (434 aa), FASTA scores: opt: 887, E(): 7.5e-48, (37.45% identity in 422 aa overlap); and similar in C-terminal region to many anthranilate synthases component I (EC 4.1.3.27) e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from Streptomyces coelicolor (511 aa), FASTA scores: opt: 509, E(): 3e-24, (40.4% identity in 255 aa overlap); P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax volcanii) (523 aa) FASTA scores: opt: 488, E(): 6.2e-23,(34.2% identity in 298 aa overlap); and similar to Q08653|TRPE_THEMA|TM0142 ANTHRANILATE SYNTHASE COMPONENT I from Thermotoga maritima (461 aa), FASTA scores: opt: 478,E(): 2.3e-22, (28.4% identity in 440 aa overlap); etc. COULD BE BELONG TO THE ANTHRANILATE SYNTHASE COMPONENT I FAMILY. Note that previously known as trpE2, an anthranilate synthase component I (EC 4.1.3.27).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26467242648076-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2407c|mbtI
MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
Bibliography
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