Gene Mb2420c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecysW
Gene length819 bp
IdentifierMb2420c
Location 2663050 bp
Protein summary information
Molecular mass29283.7 Da
Isoelectric point8.9595
Protein length272 amino acids
Cross-references
InterProIPR000515, IPR005667, IPR011866
UniProtKB/TrEMBLQ7TYP0
SWISS-MODELA0A1R3Y1W5
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYSW
CommentsMb2420c, cysW, len: 272 aa. Equivalent to Rv2398c,len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,(99.3% identity in 272 aa overlap). Probable cysW,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (287 aa), FASTA scores: opt: 765, E(): 4.1e-40, (43.8% identity in 249 aa overlap); P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa), FASTA scores: opt: 757, E(): 1.3e-39, (44.3% identity in 264 aa overlap); Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753,E(): 2.3e-39, (44.4% identity in 250 aa overlap); P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (291 aa), FASTA scores: opt: 633,E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO THE CYSTW SUBFAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS26630502663868-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2420c|cysW
MTSLPAARYLVRSVALGYVFVLLIVPVALILWRTFEPGFGQFYAWISTPAAISALNLSLLVVAIVVPLNVIFGVTTALVLARNRFRGKGVLQAIIDLPFAVSPVIVGVSLILLWGSAGALGFVEQDLGFKIIFGLPGIVLASMFVTCPFVVREVEPVLHELGTDQEQAAATLGSGWWQTFWRITLPSIRWGLTYGIVLTVARTLGEYGAVIIVSSNLPGTSQTLTLLVSDRYHRGAEYGAYALSTLLMAVSVVVLIVQMVLDAHRARAVSEG
Bibliography
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