Gene Mb2582c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE SHIKIMATE 5-DEHYDROGENASE AROE (5-DEHYDROSHIKIMATE REDUCTASE) |
| Comments | Mb2582c, aroE, len: 260 aa. Equivalent to Rv2552c,len: 269 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 260 aa overlap). Probable aroE,shikimate 5-dehydrogenase (EC 1.1.1.25), equivalent to Q9CCS7|AROE|ML0515 PUTATIVE SHIKIMATE 5-DEHYDROGENASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1452,E(): 1.8e-77, (81.5% identity in 270 aa overlap). Also highly similar, but longer 101 aa, to Q9KH59|AROE PUTATIVE SHIKIMATE DEHYDROGENASE (FRAGMENT) from Mycobacterium marinum (148 aa), FASTA scores: opt: 729, E(): 1.3e-35,(76.35% identity in 148 overlap); Q9F7W3|AROE from Mycobacterium ulcerans (148 aa), FASTA scores: opt: 718,E(): 5.9e-35, (75.7% identity in 148 aa overlap). And also similar to to others e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 572, E(): 2.8e-26,(43.4% identity in 251 aa overlap); Q98DY3|MLR4492 from Rhizobium loti (Mesorhizobium loti) (280 aa), FASTA scores: opt: 385, E(): 2.2e-15, (34.85% identity in 284 aa overlap); P74591|AROE_SYNY3|SLR1559 from Synechocystis sp. strain PCC 6803 (290 aa), FASTA scores: opt: 347, E(): 3.7e-13, (30.9% identity in 275 aa overlap); P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12 (272 aa), FASTA scores: opt: 230, E(): 7.7e-08, (29.5% identity in 251 aa overlap); etc. BELONGS TO THE SHIKIMATE DEHYDROGENASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base deletion (t-*) leads to a shorter product compared to Mycobacterium tuberculosis strain H37Rv (260 aa versus 269 aa). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2838659 | 2839441 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2582c|aroE
MLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD
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