Gene Mb2611c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable histidyl-trna synthetase hiss (histidine--trna ligase) (hisrs) (histidine--translase) |
| Comments | Mb2611c, hisS, len: 423 aa. Equivalent to Rv2580c,len: 423 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 423 aa overlap). Probable hisS,histidyl-tRNA synthetase (EC 6.1.1.21), equivalent to P46696|SYH_MYCLE|HISS|ML0494|MLCB1259.12|B1177_C3_248 HISTIDYL-TRNA SYNTHETASE from Mycobacterium leprae (427 aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85% identity in 417 aa overlap). Also highly similar to many e.g. Q9KXP2|HISS from Streptomyces coelicolor (425 aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity in 418 aa overlap); O32422|SYH_STAAU|HISS from Staphylococcus aureus (420 aa), FASTA scores: opt: 1135, E(): 7.4e-59,(44.9% identity in 412 aa overlap); P04804|SYH_ECOLI|HISS|B2514 from Escherichia coli strain K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,(43.9% identity in 417 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2872269 | 2873540 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2611c|hisS
MTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKDLTTGEQVSVSMDSVVAEVISRLAG
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