Gene Mb2690
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) |
| Comments | Mb2690, ribD, len: 258 aa. Equivalent to Rv2671,len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 258 aa overlap). Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from Mycobacterium leprae (268 aa), FASTA scores: opt: 1211,E(): 3e-68, (72.9% identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE from Pseudomonas aeruginosa (373 aa), FASTA scores: opt: 211, E(): 6.3e-06,(30.1% identity in 216 aa overlap); Q9HQA1|RIBG|VNG1256G RIBOFLAVIN-SPECIFIC DEAMINASE from Halobacterium sp. strain NRC-1 (220 aa), FASTA scores: opt: 202, E(): 1.5e-05, (27.0% identity in 174 aa overlap); O28272|RIB7_ARCFU|AF2007 PUTATIVE 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) (EC 1.1.1.193) from Archaeoglobus fulgidus (219 aa), FASTA scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 185, E(): 0.00026, (26.7% identity in 221 aa overlap); etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 PUTATIVE HYDROLASE from Streptomyces coelicolor (265 aa), FASTA scores: opt: 536, E(): 2.9e-26,(44.25% identity in 235 aa overlap); Q9RKM1|SCD17.10 PUTATIVE BIFUNCTIONAL ENZYME DEAMINASE/REDUCTASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 228,E(): 5.6e-07, (33.5% identity in 188 aa overlap); etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. SUPPOSED BELONG TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY IN THE N-TERMINAL SECTION; and TO THE HTP REDUCTASE FAMILY IN THE C-TERMINAL SECTION. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2943318 | 2944094 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2690|ribD
MPDSGQLGAADTPLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT
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