Gene Mb2698 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameechA15
Gene length831 bp
IdentifierMb2698
Location 2951649 bp
Protein summary information
Molecular mass29634.9 Da
Isoelectric point5.5998
Protein length276 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_002853
M. tuberculosis H37RvRv2679
Cross-references
InterProIPR001753, IPR018376
UniProtKB/TrEMBLQ7TY46
SWISS-MODELA0A1R3Y2P7
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ENOYL-COA HYDRATASE ECHA15 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE)
CommentsMb2698, -, len: 276 aa. Equivalent to Rv2679, len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 276 aa overlap). Probable echA15,enoyl-CoA hydratase (EC 4.2.1.17), similar to P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224 PROBABLE ENOYL-COA HYDRATASE from Mycobacterium leprae (294 aa), FASTA scores: opt: 368, E(): 2.5e-16, (32.15% identity in 277 aa overlap). Also highly similar to Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa), FASTA scores: opt: 993, E(): 2.2e-56, (58.15% identity in 263 aa overlap); and similar to many e.g. Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA scores: opt: 396, E(): 3.8e-18, (34.9% identity in 258 aa overlap); O29299|AF0963|FAD-3 from Archaeoglobus fulgidus (259 aa),FASTA scores: opt: 363, E(): 4.7e-16, (30.4% identity in 250 aa overlap); P77467|PAAG_ECOLI|B1394 from Escherichia coli strain W (262 aa), FASTA scores: opt: 357, E(): 1.1e-15, (31.75% identity in 252 aa overlap); etc. Also similar to O53163|ECHC_MYCTU|ECHA12|FADB2|Rv1472|MT1518|MTV007.19 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (285 aa), FASTA scores: opt: 355, E(): 1.6e-15, (31.3% identity in 265 aa overlap); and O06542|ECHA10|Rv1142c|MTCI65.09c|Z95584 ENOYL-COA HYDRATASE from Mycobacterium tuberculosis (268 aa). Contains PS00166 Enoyl-CoA hydratase/isomerase signature. BELONGS TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS29516492952479+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2698|echA15
MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
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