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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LRP/ASNC-FAMILY)
CommentsMb2801c, -, len: 171 aa. Equivalent to Rv2779c,len: 179 aa, from Mycobacterium tuberculosis strain H37Rv,(94.475% identity in 179 aa overlap). Possible transcriptional regulator, from the Lrp/AsnC family,similar (but longer ~30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (163 aa),FASTA scores: opt: 333, E(): 4.4e-16, (39.7% identity in 141 aa overlap); O07920|AZLB_BACSU TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Bacillus subtilis; Q9I233|PA2082 PROBABLE TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 322, E(): 2.5e-15, (33.1% identity in 148 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (33.3% identity in 120 aa overlap). Equivalent to AAK47168 from Mycobacterium tuberculosis strain CDC1551 (181 aa). SEEMS TO BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS. Start changed since first submission (+8 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa).
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30427893043304-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2801c|Mb2801c
MIILFRGHIRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLHGDARMPNNALADTVGIAPSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNLQSSARGKIRSFIQQIRRKRQGADDFILHVAARDTEDLRSFVVENLNADADVAGTQTSLIFEHLRGAAPI
      
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