Gene Mb2803
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | SECRETED L-ALANINE DEHYDROGENASE ALDb [SECOND PART] (40 KDA ANTIGEN) (TB43) |
| Comments | Mb2803, aldb, len: 239 aa. Equivalent to 3' end of Rv2780, len: 371 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 239 aa overlap). ald,secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen) (see first citations below); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081,E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, alda and aldb. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3043765 | 3044484 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2803|aldb
MSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFEGSRPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACRSNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA
Bibliography
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