Gene Mb2872c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE) (UROM) + PRECORRIN-2 OXIDASE + FERROCHELATASE |
| Comments | Mb2872c, cysG, len: 405 aa. Equivalent to Rv2847c,len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 405 aa overlap). Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-iii c-methyltransferase (EC 2.1.1.107),precorrin-2 oxidase (EC 1.-.-.-) and ferrochelatase (EC 4.99.1.-). C-terminus highly similar to many uroporphyrin-iii c-methyltransferases e.g. Q51720|COBA UROPORPHYRINOGEN III METHYLTRANSFERASE from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-ADENOSYL-L-METHIONINE:UROPORPHYRINOGEN III METHYLTRANSFERASE from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity in 245 aa overlap); P42437|NASF_BACSU|NASBE UROPORPHYRIN-III C-METHYLTRANSFERASE from Bacillus subtilis (483 aa), FASTA scores: opt: 610, E(): 2.4e-29,(42.1% identity in 240 aa overlap); etc. And highly similar over entire length to other proteins e.g. Q9L1C9|SCL11.09c UROPORPHYRINOGEN III METHYLTRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1481, E(): 5.6e-82, (58.45% identity in 409 aa overlap); Q9I0M7|CYSG|PA2611 SIROHEME SYNTHASE from Pseudomonas aeruginosa (465 aa), FASTA scores: opt: 609, E(): 2.7e-29,(34.7% identity in 444 aa overlap); P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 SIROHEME SYNTHASE from Escherichia coli stains O157:H7 and K12 (457 aa),FASTA scores: opt: 543, E(): 9.1e-27, (31.3% identity in 450 aa overlap); etc. BELONGS TO A FAMILY THAT GROUPS SUMT, CYSG, CBIF/COBM AND CBIL/COBI. Note that previously known as cysG2. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3111224 | 3112441 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2872c|cysG
MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS
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