Gene Mb2964
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 |
| Comments | Mb2964, papA5, len: 422 aa. Equivalent to Rv2939,len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 422 aa overlap). Possible papA5,conserved polyketide synthase (PKS) associated protein (see first citation below), equivalent to Q49939 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium leprae (423 aa), FASTA scores: opt: 2398, E(): 4.5e-144, (84.05% identity in 426 aa overlap); and Q02279|YMA3_MYCBO HYPOTHETICAL 38.1 KDA PROTEIN from Mycobacterium bovis (354 aa), FASTA scores: opt: 2193, E(): 3.6e-131, (97.4% identity in 343 aa overlap). And C-terminus highly similar to to Q9S381 HYPOTHETICAL 5.0 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (44 aa), FASTA scores: opt: 275, E(): 1.4e-10, (88.65% identity in 44 aa overlap). Also similar in part to various synthetases e.g. Q9AE01|RIF20 RIF20 PROTEIN from Amycolatopsis mediterranei (Nocardia mediterranei) (403 aa), FASTA scores: opt: 282, E(): 2.7e-10, (30.3% identity in 393 aa overlap); middle part of Q00869|ESYN1 ENNIATIN SYNTHETASE (FRAGMENT) (N-methyl peptide synthetase) from Fusarium equiseti (3131 aa),FASTA scores: opt: 180, E(): 0.0036, (26.85% identity in 242 aa overlap); N-terminus of Q9FB18 PEPTIDE SYNTHETASE NRPS2-1 from Streptomyces verticillus (2626 aa), FASTA scores: opt: 159, E(): 0.068, (23.65% identity in 351 aa overlap); etc. Note that Rv2939|papA5 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3231522 | 3232790 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb2964|papA5
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME
Bibliography
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