Gene Mb3005c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameddlA
Gene length1113 bp
IdentifierMb3005c
Location 3293365 bp
Protein summary information
Molecular mass39252.8 Da
Isoelectric point5.0078
Protein length370 amino acids
Cross-references
UniProtKB/TrEMBLX2BMD9, Q7TXH9
SWISS-MODELQ7TXH9
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE)
CommentsMb3005c, ddlA, len: 370 aa. Equivalent to Rv2981c,len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,(98.9% identity in 373 aa overlap). Probable ddlA (alternate gene name: ddl), D-alanine--D-alanine ligase A (EC 6.3.2.4), equivalent to Q9CBS0|Q9CBS0 D-ALANINE-D-ALANINE LIGASE A from Mycobacterium leprae (384 aa), FASTA scores: opt: 2001, E(): 2.4e-115, (81.75% identity in 367 aa overlap); and Q9ZGN0|DDL_MYCSM D-ALANINE--D-ALANINE LIGASE from Mycobacterium smegmatis (373 aa), FASTA scores: opt: 1934, E(): 3.1e-111, (77.95% identity in 372 aa overlap). Also highly similar to others e.g. Q9ZBR9|DDL_STRCO from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1187, E(): 2.2e-65, (52.0% identity in 379 aa overlap); P15051|DDLA_SALTY from Salmonella typhimurium and Salmonella typhi (363 aa),FASTA scores: opt: 946, E(): 1.3e-50, (44.5% identity in 364 aa overlap); P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS0431 from Escherichia coli strain O157:H7 and K12 (364 aa), FASTA scores: opt: 938, E(): 3.9e-50, (43.55% identity in 363 aa overlap); etc. Contains PS00843 D-alanine--D-alanine ligase signature 1. BELONGS TO THE D-ALANINE--D-ALANINE LIGASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 9 bp deletion (acgccggtc-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (370 aa versus 373 aa).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS32933653294477-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3005c|ddlA
MSANDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLHRQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELECGVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLATMIETALARGVGLH
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