Gene Mb3092
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | MULTIDRUGS-TRANSPORT INTEGRAL MEMBRANE PROTEIN MMR |
| Comments | Mb3092, mmr, len: 107 aa. Equivalent to Rv3065,len: 107 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 107 aa overlap). mmr, integral membrane multidrugs resistance transporter (see citation below), equivalent to Q9CBP1|ML1756 PROBABLE MULTIDRUG RESISTANCE PROTEIN from Mycobacterium leprae (107 aa),FASTA scores: opt: 534, E(): 3.3e-28, (77.55% identity in 107 aa overlap). Also highly similar to bacterial proteins involved in resistance to ethidium bromide or methyl viologen e.g. O87866|QACG_STASP QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACG (QUARTERNARY AMMONIUM DETERMINANT G) from Staphylococcus sp. strain ST94 (107 aa), FASTA scores: opt: 307, E(): 1.8e-13, (39.8% identity in 103 aa overlap); P96460|QAC QUATERNARY AMMONIUM COMPOUNDS RESISTANCE PROTEIN QAC from Staphylococcus aureus (107 aa), FASTA scores: opt: 304, E(): 2.8e-13,(40.4% identity in 104 aa overlap); Q57225|QACE_ECOLI QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACE (QUARTERNARY AMMONIUM DETERMINANT E) from Escherichia coli (110 aa), FASTA scores: opt: 300, E(): 5.2e-13, (48.15% identity in 108 aa overlap); AAG55967|Z1870 METHYLVIOLOGEN RESISTANCE PROTEIN ENCODED WITHIN PROPHAGE CP-933X from Escherichia coli strain O157:H7 EDL933 (110 aa); P23895|EMRE|MVRC|EB|B0543 EMRE PROTEIN from Escherichia coli (110 aa), FASTA scores: opt: 290, E(): 2.3e-12,(43.55% identity in 101 aa overlap); etc. Also similar to the SugE protein of enteric bacteria. BELONGS TO THE SMALL MULTIDRUG RESISTANCE (SMR) PROTEIN FAMILY. Note that previously known as emrE. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3386934 | 3387257 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3092|mmr
MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLGSPISVMKVVGVGLIVVGVVTLNLAGAH
Bibliography
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