Gene Mb3165
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4 (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN) |
| Comments | Mb3165, fadB4, len: 323 aa. Equivalent to Rv3141,len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 323 aa overlap). Probable fadB4,quinone oxidoreductase (EC 1.6.5.5), showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35,(39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32,(40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23,(34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% identity in 322 aa overlap); etc. Also similar to Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (325 aa), FASTA scores: opt: 673,E(): 7.2e-32, (40.2% identity in 326 aa overlap); and Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (332 aa), FASTA scores: opt: 623,E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03,MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. TBparse score is 0.904. Thought to be differentially expressed within host cells (see first citation below). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3463204 | 3464175 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3165|fadB4
MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALLTRGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPERVFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPALGASRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRFTDSLRSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLERLLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD
Bibliography
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