Gene Mb3177
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I) |
| Comments | Mb3177, nuoI, len: 211 aa. Equivalent to Rv3153,len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,(99.5% identity in 211 aa overlap). Probable nuoI, NADH dehydrogenase I, chain I (EC 1.6.5.3), similar to others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa),FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in 164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus (subsp. thermophilus) (182 aa), FASTA scores: opt: 543,E(): 1.8e-26, (50.9% identity in 163 aa overlap); Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa overlap); etc. Contains two 4Fe-4S ferredoxins,iron-sulfur binding region signatures (PS00198). BELONGS TO THE COMPLEX I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. COFACTOR: BINDS TWO 4FE-4S CLUSTERS. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3475616 | 3476251 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3177|nuoI
MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGSMFKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGADNTEEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYEKDRLLAPLLPEMAAPPHPRAPGATDKDYYLGNVTAEGLRGVRESQTTGDSR
Bibliography
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