Gene Mb3202c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE EPOXIDE HYDROLASE MESTA [FIRST PART] (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) |
| Comments | Mb3202c, mesTa, len: 208 aa. Equivalent to 5' end of Rv3176c, len: 318 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 201 aa overlap). Probable mesT, epoxide hydrolase (EC 3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa),FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa),FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3501924 | 3502550 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3202c|mesTa
MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAAGTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFERADLVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGGIFADGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPSSRADTH
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