Gene Mb3203
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE) |
| Comments | Mb3203, -, len: 286 aa. Equivalent to Rv3177, len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 286 aa overlap). Possible peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746,E(): 1.1e-39, (43.25% identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4% identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa),FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO-AND CHLORO-PEROXIDASES) (274 aa),FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3502697 | 3503557 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3203|Mb3203
MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFLHHLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALGFDQVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKATLTFRDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQKPSDLTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDALQFLES
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