Gene Mb3222c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable atp-dependent dna helicase ii uvrd2 |
| Comments | Mb3222c, UvrD2, len: 700 aa. Equivalent to Rv3198c,len: 700 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 700 aa overlap). Probable UvrD2, DNA helicase II homolog (EC 3.6.1.-), equivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa overlap); and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, (82.5% identity in 234 aa overlap); products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, (52.05% identity in 728 aa overlap); P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa overlap); O83991|TP1028 DNA HELICASE II (UVRD) from Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3523654 | 3525756 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3222c|uvrD2
MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHRIASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAYRQLRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIGPEEYVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIENDAAVAEEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGPVPSFHEHSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAYQVRGGEGFFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARERWEALTALAELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPGGRQSRKPSRFLNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETCAADVDEELLLQLKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGARKLEQYGSDVLQLVRGRT
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