Gene Mb3267c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN |
| Comments | Mb3267c, -, len: 1048 aa. Equivalent to Rv3239c,len: 1048 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1048 aa overlap). Probable conserved transmembrane protein, organised in two domains. Domain comprising first ~500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216); e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second part, corresponding to last 550 aa residues, is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kd protein from Mycobacterium tuberculosis (583 aa),FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa overlap); and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS). |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3569057 | 3572203 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3267c|Mb3267c
MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVNIAFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTIASGLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAIAAGLGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGALLLAVTLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLRSRSFVAGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAALGRVAGRHGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPVLSSAALAEVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWAMAAICFIAVAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDADPLGNLPLFAGLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDSIVLKELGRGEVLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKVLATRLREAPPPATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDRDGLDRAERVADKVVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADLVLAGPAASREHRRQWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGARGFAHLGVLDELERVGVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLSDYAFPVRGLVHGRRTLTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDVIGCSLRLPGIYPPQVYNGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSARQDGSPKVPGIGDTLMRTMTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREAGRVAAREAMPHIMALLNR
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