Gene Mb3293c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | dtdp-rha:a-d-glcnac-diphosphoryl polyprenol,a-3-l-rhamnosyl transferase wbbl1 (alpha-l-rhamnose-(1->3)-alpha-d-glcnac(1->p)-p-decaprenyl) |
| Comments | Mb3293c, wbbL1, len: 297 aa. Equivalent to Rv3265c,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(98.7% identity in 301 aa overlap). Probable wbbL1,dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE (EC 2.-.-.-) (see citation below), equivalent to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE from Mycobacterium leprae (308 aa), FASTA scores: opt: 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and Q9RN50|WBBL|Q9RN49 (see note * below) DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL,A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% identity in 293 aa overlap). Note that previously known as wbbL. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme,dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P.,Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W.,Pan F., Kimbrel S., Kundu M., McNeil M.]. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3600579 | 3601472 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3293c|wbbL1
MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVRRSRRRKLKLVEGRH
Bibliography
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