Gene Mb3321
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE) |
| Comments | Mb3321, pcd, len: 494 aa. Equivalent to Rv3293,len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 494 aa overlap). Probable pcd,piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-),highly similar to others e.g. O85725|PCD SEMIALDEHYDE DEHYDROGENASE from Streptomyces clavuligerus (512 aa),FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see first citation below); Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter crescentus (507 aa), FASTA scores: opt: 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from Streptomyces clavuligerus (496 aa), FASTA scores: opt: 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) (see second citation below); etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Previously known as aldB. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3628127 | 3629611 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3321|pcd
MLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALVARLGELLTAHQQDLATLVTVEVGKITAEARGEVQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLVDDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRCIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAYRDMVAALERARTDGGEVIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLSSSIFTTDLREAEHFLDQSDCGIANVNIGTSGAEIGGAFGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG
Bibliography
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