Gene Mb3345 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesdhC
Gene length339 bp
IdentifierMb3345
Location 3658627 bp
Protein summary information
Molecular mass12837.4 Da
Isoelectric point9.1415
Protein length112 amino acids
Orthologs
M. tuberculosis H37RvRv3316
M. tuberculosis MTBC0mtbc0_003526
Cross-references
InterProIPR000701, IPR014314
UniProtKB/TrEMBLQ7TWR3
SWISS-MODELA0A1R3Y3S5
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE SUCCINATE DEHYDROGENASE (CYTOCHROME B-556 SUBUNIT) SDHC (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
CommentsMb3345, sdhC, len: 112 aa. Equivalent to Rv3316,len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 112 aa overlap). Probable sdhC,cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39,(88.4% identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa), FASTA scores: opt: 195, E(): 1.7e-06, (36.8% identity in 87 aa overlap); Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E(): 2.9e-06, (37.85% identity in 74 aa overlap); P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa), FASTA scores: opt: 183, E(): 1.1e-05, (35.15% identity in 74 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS36586273658965+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3345|sdhC
MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKTPIVGLMEYGLVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVVVGIHMWEHFR
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