Gene Mb3433 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb3433
Gene length789 bp
IdentifierMb3433
Location 3769576 bp
Protein summary information
Molecular mass28227.7 Da
Isoelectric point5.7076
Protein length262 amino acids
Orthologues
M. tuberculosisRv3400
Cross-references
UniProtKB/TrEMBLX2BNW1, P65070
SWISS-MODELP65070
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE HYDROLASE
CommentsMb3433, -, len: 262 aa. Equivalent to Rv3400, len: 262 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 262 aa overlap). Probable hydrolase (EC 3.-.-.-), strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from Streptomyces coelicolor (246 aa), FASTA scores: opt: 888,E(): 7.7e-47, (56.35% identity in 245 aa overlap); Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05,(29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa overlap); O06995|PGMB_BACSU|YVDM PUTATIVE BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa),FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in 245 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),FASTA scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa overlap). Interestingly, note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37695763770364+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3433|Mb3433
MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAWKAMFDAYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDGSPDDPGAAETVYGLGNRKNDMLHKLLRDDGAQVFDGSRRYLEAVTAAGLGVAVVSSSANTRDVLATTGLDRFVQQRVDGVTLREEHIAGKPAPDSFLRAAELLGVTPDAAAVFEDALSGVAAGRAGNFAVVVGINRTGRAAQAAQLRRHGADVVVTDLAELL
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